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[Thr4,Gly7]-Oxytocin

Name
[Thr4,Gly7]-Oxytocin
Molecular structural formula
Purity
≥95%
CAS Number
60786-59-6
Formula
C39H61N11O12S2
MW
940.1
Target
Oxytocin Receptor; Potassium Channel
Sequence
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2(Disulfide bridge:Cys1-Cys6)
Sequence Shortening
CYITNCGLG-NH2(Disulfide bridge:Cys1-Cys6 )
Solubility in water
100mg/mL
References
[1]. Lily R Barrett, et al. Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology. 2021 Apr;46(5):1045-1056. [2]. Binqi Hu, et al. Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms. Cereb Cortex. 2021 Mar 31;31(5):2402-2415. [3]. M R Melis, et al. Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning. Regul Pept. 1997 Mar 26;69(2):105-11.
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(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels.